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Psychopathology in relatives

How is psychopathology relevant to relatives of people with bipolar disorder?

Due to the significant genetic loading of bipolar disorder, first-degree relatives of people with bipolar disorder may also show signs of psychopathology.

What is the evidence for psychopathology in families of people with schizophrenia?

Moderate to high quality evidence suggests a large increased risk of bipolar disorder in first-degree relatives of people with bipolar disorder. There is also a medium-sized increased risk of attention deficit hyperactivity disorder, oppositional defiant disorder, and conduct disorder, and a small increased risk of a substance use disorder in relatives. Moderate quality evidence suggests medium-sized increased risks of other mood or anxiety disorders.

June 2020

Last updated at: 10:51 pm, 22nd June 2020
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Fact Sheet Technical Commentary

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.