Fluoxetine

What is fluoxetine?

Fluoxetine is a widely prescribed antidepressant due to its efficacy and safety profile. It is a selective inhibitor of serotonin reuptake and has little effect on other neurotransmitters. It is often prescribed for bipolar disorder along with the antipsychotic olanzapine.

What is the evidence for fluoxetine as treatment for bipolar disorder?

Moderate to high quality evidence suggests greater improvement in depression with combined olanzapine and fluoxetine when compared to placebo, olanzapine or lamotrigine alone. Low quality evidence is unable to determine the benefits or risks of fluoxetine alone for bipolar disorder.

April 2019

Last updated at: 4:08 am, 2nd April 2019
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Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.