What is fluoxetine for bipolar disorder?

Fluoxetine is a widely prescribed antidepressant due to its efficacy and safety profile. It is a selective inhibitor of serotonin reuptake and has little effect on other neurotransmitters. It is often prescribed for bipolar disorder along with the antipsychotic olanzapine.

What is the evidence for fluoxetine as treatment for bipolar disorder?

Moderate to high quality evidence suggests greater improvement in depression with combined olanzapine and fluoxetine when compared to placebo, olanzapine or lamotrigine alone. Low quality evidence is unable to determine the benefits or risks of fluoxetine alone.

November 2021

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Last updated at: 1:58 pm, 15th February 2022
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