What is zonisamide?

Zonisamide is an anticonvulsant used primarily in the treatment of seizure disorders such as epilepsy. Anticonvulsant medications influence the actions of neurotransmitters leading to a decrease in brain cell (neuron) excitability. In bipolar disorder, zonisamide is used mainly for the treatment of bipolar depression.

What is the evidence for zonisamide as a treatment for bipolar disorder?

Moderate to low quality evidence suggests zonisamide may be effective for general clinical improvement and depression, however, when compared to placebo there were no differences between groups in mania, hypomania, or mixed symptoms.

July 2020

Last updated at: 4:49 am, 7th July 2020
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