Zonisamide

What is zonisamide?

Zonisamide is an anticonvulsant used primarily in the treatment of seizure disorders such as epilepsy. Anticonvulsant medications influence the actions of neurotransmitters leading to a decrease in brain cell (neuron) excitability. In bipolar disorder, zonisamide is used mainly for the treatment of bipolar depression.

What is the evidence for zonisamide as a treatment for bipolar disorder?

Moderate to low quality evidence suggests zonisamide may be effective for general clinical improvement and depression, however when compared to placebo there were no differences between groups in mania, hypomania or mixed symptoms.

April 2019

Last updated at: 6:23 am, 2nd April 2019
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NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.