Cognition in schizophrenia and bipolar disorder

Why compare cognition in schizophrenia and bipolar disorder? 

Cognitive deficits are core features of both schizophrenia and bipolar disorder. Establishing differences in cognition between these disorders may be useful for identifying differences in the underlying illness pathologies, and may provide potential targets for individual treatments.

What is the evidence for cognitive functioning in schizophrenia and bipolar disorder?

Moderate to high quality evidence shows small to medium-sized effects of poorer executive functioning, social cognition and psychomotor speed in people with schizophrenia compared to people with bipolar disorder. There are also medium-sized effects of poorer verbal immediate memory, verbal delayed memory and visual delayed memory in people with schizophrenia.

Moderate to high quality evidence finds a medium-sized effect of poorer pre-illness onset cognitive functioning and a large effect of poorer post-illness onset cognitive functioning in people with schizophrenia compared to controls. In people with bipolar disorder compared to controls, there was a small effect of poorer pre-illness onset cognitive functioning and a medium-sized effect of poorer post-illness onset cognitive functioning.

July 2019

Last updated at: 7:57 am, 26th July 2019
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