Adenosine modulators

What are adenosine modulators?

Bipolar disorder is thought to be associated with a purinergic system dysfunction, particularly in the manic phases of the disorder. Moreover, depressive temperaments have been related to both high and low levels of uric acid. Allopurinol is used for the treatment of gout and hyperuricemia; it inhibits purine degradation and subsequently increases adenosine levels.

What is the evidence for adenosine modulators?

Moderate quality evidence suggests adjunctive allopurinol may improve mania symptoms in people with bipolar disorder, but not for those in a mixed mood state.

March 2019

Last updated at: 4:12 am, 1st April 2019
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NeuRA Libraries

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