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Insights for families

Schizophrenia has a large genetic component and as such, families of people with schizophrenia may also be affected by the disorder. This topic assesses the impact of schizophrenia on the family unit, and also cognitive and physiological alterations in relatives.

Cognition in first-degree relatives

How is cognition in families related to schizophrenia?  Cognitive deficits have been reported in people with schizophrenia. Deficits in memory, attention and executive functioning are most commonly reported, with lesser degree of dysfunction in perceptual and language processes. Cognitive deficits are present early in the course of the disorder and are stable over time, and may be heritable. First-degree relatives of people with schizophrenia may show attenuated signs of cognitive deficits. If cognitive deficits found in people with schizophrenia are also found in their relatives, this may be suggestive of the underlying genetic basis. This is particularly informative in disorders…

Collection of family history

How can family history be used in assessing schizophrenia?  The collection of information relating to a person’s family history of mental illness can be a valuable tool for diagnosing and understanding their current mental state, in both clinical and research settings, where it may not be feasible to interview the family members themselves. What is the evidence for the family history method? The only evidence regarding family history method is moderate quality and suggests that a patient can usually correctly identify a particular family member with schizophrenia, if one exists. August 2020

Familial coaggregation with bipolar disorder

What is familial coaggregation?  Familial coaggregation is the rate of related disorders found in a family. Many studies have suggested a fundamental association between schizophrenia and bipolar disorder. Many family studies have investigated the possibility of this association by assessing whether schizophrenia and bipolar disorder diagnoses may cluster within the same extended family. What is the evidence for familial coaggregation of schizophrenia and bipolar disorder? Moderate to low quality evidence suggests high familial coaggregation of schizophrenia and bipolar disorder, with first-degree relatives of patients with schizophrenia or bipolar showing an increased risk of developing either disorder. August 2020

Family relationships

How is schizophrenia impacted by family relationships? Several familial traits have been associated with increased risk for schizophrenia. These include; familial high expressed emotion (hostility, emotional over-involvement, and critical comments); negative parental affective style (guilt induction, over-intrusiveness, and personal criticism); and communication deviance (lack of clarity in communication). What is the evidence for family relationships? Moderate quality evidence finds people with schizophrenia may have had poor relationships with parents during childhood, with increased family instability, high communication deviance, negative emotions, and poor self-concept. Moderate to high quality evidence suggests increased familial expressed emotion is related to more relapses in patients….

Impact on families

How does schizophrenia impact on families? A diagnosis of schizophrenia can have a large impact not only on the affected individuals, but also on the people closest to them. This topic considers the impact of schizophrenia on family members, and on the family as a unit. Sometimes the family of a person with schizophrenia may experience different types of burden, particularly during acute phases of the illness. Burden is considered in terms of objective effects, such as illness severity or financial output, but also in terms of subjective effects, such as the emotional impact of the illness on family members….

Physical anomalies in first-degree relatives

How are physical abnormalities relevant to families of people with schizophrenia?  Relatives of people with schizophrenia may show attenuated signs of the illness, such as physical features that are commonly identified with the disorder. Identifying these signs can help determine how genetics may contribute to the risk of schizophrenia. What is the evidence for physical abnormalities in family members? High quality evidence shows decreased rates of any cancer in relatives compared to the general population, similarly to findings in people with schizophrenia. High quality evidence shows relatives have impairment in closed loop gain during smooth pursuit eye movement tasks. Moderate…

Psychopathology in first-degree relatives

We have not found any systematic reviews on this topic that meet our inclusion criteria. Pending enough primary studies, we invite reviews on this topic to be conducted. Alternatively we will endeavour to conduct our own review to fill this gap in the Library. August 2020


What is sibship? Sibship is a medical term meaning a group of individuals born of the same parents. Factors associated with sibship include birth order, number of siblings or number of births in the family, and inter-birth interval periods. It is not known how these factors may be associated with risk for schizophrenia. What is the evidence for sibship? Moderate quality evidence suggests a small to medium-sized increased risk of schizophrenia in people who had one, four or five births in their family, or in children born less than 18 months before or after their closest sibling. First birth order…

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.