Imipramine

What is imipramine for bipolar disorder?

Imipramine is a tricyclic antidepressant that is widely prescribed for both depression and anxiety. It works by increasing levels of serotonin and norepinephrine and by blocking certain serotonin, adrenergic, histamine, and cholinergic receptors.

What is the evidence for imipramine as treatment for bipolar disorder?

Low quality evidence is unable to determine the benefits of imipramine for bipolar disorder.

Review authors conclude that the existing evidence does not support the use of imipramine for bipolar disorder.

November 2021

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Last updated at: 4:20 pm, 29th November 2021
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