Imipramine

What is imipramine?

Imipramine is a tricyclic antidepressant that is widely prescribed for both depression and anxiety. It works by increasing levels of serotonin and norepinephrine and by blocking certain serotonin, adrenergic, histamine, and cholinergic receptors.

What is the evidence for imipramine as treatment for bipolar disorder?

Low quality evidence is unable to determine the benefits of imipramine for bipolar disorder.

Review authors conclude that the existing evidence does not support the use of antidepressants in general for people with bipolar disorder.

April 2019

Last updated at: 4:12 am, 2nd April 2019
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Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.