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Insulin-like growth factor

What is insulin-like growth factor-1?

Insulin-like growth factor-1 (IGF-1) is a 70-amino acid peptide, primarily produced in the central nervous system and peripheral tissues such as the liver, and regulated via growth hormone secretion. IGF-1 interacts with the central nervous system under conditions of neuroinflammation and neurodegeneration. It also helps in neurogenesis, myelination, remyelination, neuromodulation, and synaptogenesis, which are all impaired in affective disorders, including bipolar disorder.

What is the evidence for changes in insulin-like growth factor-1 in people with bipolar disorder?

Moderate to high quality evidence suggests a medium-sized effect of increased peripheral IGF-1 levels in people with bipolar disorder, which is similar to levels found in people with major depression when compared to controls.

July 2020

Last updated at: 5:31 am, 10th July 2020
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Fact Sheet Technical Commentary

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.