Norepinephrine inhibitors

What is atomoxetine?

Atomoxetine is a norepinephrine (noradrenaline) reuptake inhibitor used to treat Attention Deficit Hyperactivity Disorder (ADHD). Studies on people with bipolar disorder show rates of comorbid ADHD range from 12.8% to 16%, which is higher than observed in the general population. Having both ADHD and bipolar disorder is associated with more severe symptoms and worse outcomes of both conditions, including earlier onset of bipolar disorder, more mood episodes, shorter inter-episodic phases, and generally, greater functional impairment.

What is the evidence for atomoxetine?

Low quality evidence is unable to properly determine any benefits of atomoxetine for people with comorbid ADHD and bipolar disorder.

Review authors conclude that atomoxetine could be effective in the treatment of ADHD symptoms in this population, however there is a small increased risk of manic switches and destabilisation of the mood disorder.

March 2019

Last updated at: 6:03 am, 1st April 2019
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Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.