Our response to COVID-19

We're supporting people to maintain their wellbeing and manage isolation.

Complex I and IV

What is complex I and complex IV?

The electron transport chain involves a series of complexes that transfer electrons from donors to acceptors via reduction-oxidation reactions. Complex I is the first and largest enzyme in the electron transport chain, while complex IV is the last enzyme in the chain. Both of these complexes have been found to be altered in psychiatric disorders. The remaining complexes have been studied to a lesser degree.

What is the evidence for complex I and IV alterations in people with bipolar disorder?

Moderate quality evidence suggests small to medium-sized effects of lower complex I levels in bipolar disorder in subunits NDUFS1 in the cerebellum, striatum, and frontal cortex, with complex I subunit NDUFS7 also reduced in the frontal cortex. There were no significant changes in complex IV levels.

July 2020

Last updated at: 3:24 am, 10th July 2020
To view documentation related to this topic download the files below
Fact Sheet Technical Commentary

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.