Blonanserin

What is blonanserin?

Second generation antipsychotics (sometimes referred to as ‘atypical’ antipsychotics) such as blonanserin are a newer class of antipsychotic medication than first generation ‘typical’ antipsychotics. Second generation antipsychotics are effective for the positive symptoms of schizophrenia. It is sometimes claimed that they are more effective than first generation antipsychotics in treating the negative symptoms of schizophrenia, although the evidence for this is weak. Negative symptoms include a lack of ordinary mental activities such as emotional expression, social engagement, thinking and motivation, whereas positive symptoms include the experiences of perceptual abnormalities (hallucinations) and fixed, false, irrational beliefs (delusions). Second generation antipsychotics may also cause less extra-pyramidal side effects. These include dyskinesias such as repetitive, involuntary, and purposeless body or facial movements, Parkinsonism (cogwheel muscle rigidity, pill-rolling tremor and reduced or slowed movements), akathisia (motor restlessness, especially in the legs, and resembling agitation) and dystonias such as muscle contractions causing unusual twisting of parts of the body, most often in the neck. These effects are caused by the dopamine receptor antagonist action of these drugs.

What is the evidence for blonanserin?

Compared to haloperidol, moderate quality evidence suggests blonanserin may be more effective for negative symptoms, with no differences for other symptoms. No differences were found on any comparison with risperidone. Compared to risperidone, high quality evidence suggests a lower risk of hyperprolactinemia with blonanserin, although moderate quality evidence suggests a higher risk of akathisia. Compared to haloperidol, moderate quality evidence suggests a lower risk of dizziness and akathisia with blonanserin.
March 2019
Last updated at: 9:14 pm, 22nd March 2019
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Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.