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What is oestrogen?

Oestrogen is a hormone that has been proposed to confer a protective effect for schizophrenia. This theory is based on the observations that women tend to have a later age of onset of schizophrenia than men, and have a second peak of onset after menopause. In women, oestrogen levels drop with age, particularly with the onset of menopause. This protective effect may mean that pre-menopausal women who develop schizophrenia may experience a less severe illness than males. Oestrogens are not used routinely for people with schizophrenia; however some studies have trialed the use of oestrogen as an additional, adjunctive treatment to standard antipsychotic treatment.

What is the evidence for oestrogen?

Moderate to high quality evidence indicates small to medium-sized improvements in positive and negative symptoms in females with schizophrenia taking adjunctive oestrogen. There were medium-sized improvements in symptoms in both males and females (including those postmenopausal) with adjunctive raloxifene compared to placebo, with no differences in depression symptoms or cognition.

September 2020

Last updated at: 5:30 am, 30th September 2020
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Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.