Our response to COVID-19

We're supporting people to maintain their wellbeing and manage isolation.

Treatments for hypersalivation

What is hypersalivation? 

Antipsychotic medications such as clozapine and olanzapine, among others, may induce excessive (hyper) salivation, which can be uncomfortable and embarrassing as well as increasing the risk of aspiration pneumonia. Various pharmacological approaches have been used to try and alleviate this problem. Adjunctive medications prescribed to treat such side effects may contribute to increasing adherence to antipsychotic medications, which reduces the risk of psychotic relapse.

What is the evidence for adjunctive therapies to relieve hypersalivation?

Moderate to low quality evidence suggests antimuscarinic may be more effective than placebo for reducing clozapine-induced hypersalivation. Traditional Chinese medicine (SuoQuan Wan) and rice bran oil derivative (oryzanolum) may be more effective than doxepin (antimuscarinic) for reducing clozapine-induced hypersalivation and may cause less constipation.

August 2019

Last updated at: 11:56 pm, 1st September 2019
To view documentation related to this topic download the files below
Fact Sheet Technical Commentary

NeuRA Libraries

Title Colour Legend:
Green - Topic summary is available.
Orange - Topic summary is being compiled.
Red - Topic summary has no current systematic review available.